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Research shows intranasal vaccination with IL-12 highly effective

Dennis Metzger of Albany Medical College (Albany, New York) has presented research at the Society for General Microbiology Spring Conference demonstrating the effectiveness of using interleukin-12 (IL-12) in combination with intranasally-delivered vaccines to boost immune response. The study tested the effectiveness of these vaccines in mice against influenza virus, … [Read more...] about Research shows intranasal vaccination with IL-12 highly effective

Dymista 40% better than fluticasone alone in Phase 3 study

According to Meda Pharmaceuticals, a Phase 3 trial has shown that its Dymista nasal spray, a combination formulation of azelastine hydrochloride and fluticasone propionate, produced a 40% greater improvement in nasal symptoms than fluticasone alone. Meda is presenting the results at the 2011 annual meeting of the American Academy of Asthma, Allergy and Immunology … [Read more...] about Dymista 40% better than fluticasone alone in Phase 3 study

Positive results for Vectura inhaled heparin formulation

Vectura's VR496, an inhaled dry powder formulation of heparin sodium, has produced positive results in a Phase 2 study in cystic fibrosis patients, says the company. The product has received orphan drug status from both the EMA and the FDA. The study involved 77 CF patients, with 90% completing the 4-week treatment period. Patients treated with VR496 experienced … [Read more...] about Positive results for Vectura inhaled heparin formulation

Study shows tiotropium better than salmeterol for preventing COPD exacerbations

Results from the Prevention Of Exacerbations with Tiotropium in COPD (POET-COPD) study published in the New England Journal of Medicine show a significant reduction in exacerbations for COPD patients treated with tiotropium compared to those treated with salmeterol. The one-year study involved almost 7400 patients with moderate to severe COPD, half of whom were … [Read more...] about Study shows tiotropium better than salmeterol for preventing COPD exacerbations

Phase 3 studies planned for nasal mist dental anesthesia

After a favorable end-of-Phase 2 meeting with the FDA, St. Renatus has announced that it plans to proceed to Phase 3 studies of its dental anesthetic, which is delivered as a nasal mist via a syringe. The nasally-administered anesthetic numbs the patient's teeth without numbing the face and lips. According to St. Renatus, the Phase 2 results showed that the nasal … [Read more...] about Phase 3 studies planned for nasal mist dental anesthesia

Phase 2 study of inhaled Bimosiamose produces positive results

German biopharmaceutical company Revotar has announced that its Bimosiamose inhalation solution for the treatment of COPD met its primary endpoint in a Phase 2 study involving more than 75 patients with moderate-to-severe COPD. Bimosiamose is a pan-selectin antagonist that the company is developing for asthma and acute lung injury in addition to COPD. According to … [Read more...] about Phase 2 study of inhaled Bimosiamose produces positive results