In the same session, John Patton of Kindeva spoke about “Nasal and Pulmonary Immunology: Choosing the Optimal Vaccine Delivery Route,” explaining that many mucosal sites have paired corresponding sites elsewhere in the body, so that a vaccine delivered to the nose will also stimulate an immune response in the urogenital tract, for example, and an epidermal vaccine will stimulate a strong response in the lung. To take advantage of that knowledge, he advocated designing aerosol vaccines that will deposit in both the nose and the lung with the goal being to “paint every room in the house.”
2024 Pat Burnell Young Investigator Award Winner Stefania Glieca of the University of Parma presented her work on “Lactobacilli Inhalation Powders as Antibacterial Agents against S. Aureus” in the Posters on the Podium session. In the same session, Chun Yuen Jerry Wong of Macquarie University & Woolcock Institute presented his poster, “Optimizing Intranasal Delivery of Peptides for Targeted Brain Drug Delivery in Transgenic Mouse Models of Alzheimer’s Disease,” in which he discussed the advantages of nose to brain delivery, formulation of a cyclic peptide, evaluation of delivery techniques, and successful delivery of the peptide to the brain in a mouse model of Alzheimer’s disease.
Paulo Lina of Hovione addressed the use of a protein-based excipient for inhaled formulations in his talk titled “β-Lactoglobulin, A Novel Excipient for Next Generation Spray-Dried Powder Formulations.” Lina described the use of Zerion Pharma’s Dispersome to improve aerosolization in spray dried composite formulations, resulting in significant increases in fine particle fraction.
Several exhibitors highlighted their expertise in large molecule OINDPs throughout the conference. Catalent presented a workshop titled, “Biologics for Nebulization: An Approach to Formulate and Manufacture,” including a detailed discussion of formulation challenges and methods for biologics. Hovione also presented a workshop on formulation of biologics, titled, “Optimizing Biologics Powder Formulations: Achieving High Drug Load, Stability, and Efficient Inhalation.” In its workshop on “An Expanded Toolbox for Respirable Dry Powders: Pulmonary and Intranasal Delivery for Small and Biotherapeutic APIs,” Lonza presented case studies related to development of dry powder vaccines for pulmonary and nasal delivery.
CDMO Intertek, which sponsors an annual forum on inhaled and nasal biologics and DNA, promoted those services in the exhibition and announced an expansion of its inhaled biologics testing facilities at the beginning of the conference.
