Arcturus Therapeutics announced that it initiated 2 studies in December 2024, one of which is a Phase 2 MAD trial of ARCT-032 inhaled mRNA therapy in cystic fibrosis patients. The company announced in September 2024 that the FDA had cleared its IND for the study, which is expected to enroll 12 adults with CF who do not benefit from CFTR modulators and will evaluate 3 dose levels of the lipid nanoparticle formulation. Participants will receive ARCT-032 via nebulization every day for 28 days.
Arcturus Chief Scientific Officer Pad Chivukula commented, “We are very pleased with the recent progress in our Phase 2 studies in people with cystic fibrosis and OTC deficiency. ARCT-032 has the potential to address the significant unmet medical need in the CF community for those who do not qualify for or benefit from available treatment options.”
Read the Arcturus Therapeutics press release
