Armata Pharmaceuticals announced that it has completed the Phase 1b/2a SWARM-P.a. trial of its AP-PA02 inhaled phage cocktail in cystic fibrosis patients who have chronic P. aeruginosa lung infections. The SWARM-P.a. study was initiated in 2020 with support from the Cystic Fibrosis Foundation. In October 2021, the Cystic Fibrosis Foundation and Innoviva made equity investments in Armata to support development of AP-PA02.
Armata CEO Brian Varnum said, “The completion of SWARM-P.a. represents a critical milestone for our lead program and for Armata. I would like to once again express Armata’s gratitude to the Cystic Fibrosis Foundation for its ongoing support and guidance. This trial will provide critical information regarding inhaled delivery of phage, importantly, assessment of safety and tolerability of phage therapy in the CF population. Additionally, this first-in-human Phase 1b/2a study will provide critical insights for dosing paradigms required to meet microbiological endpoints. We anticipate topline data in the first quarter of 2023.”
Senior VP of Clinical Development Mina Pastagia commented, “We are very pleased to have completed Armata’s first multi-center, double-blind, randomized, placebo-controlled clinical trial evaluating phage therapy in patients. Successful use of phage therapy has been reported in compassionate use cases, but its translation into standard clinical practice requires rigorous, systematic clinical trials. We look forward to evaluating the clinical data from CF subjects in our SWARM-P.a. study to take Armata one step closer to that goal.”
Read the Armata Pharmaceuticals press release.
