The COPD Foundation has partnered with ENA Respiratory for development of ENA’s INNA-051 pegylated TLR2/6 agonist pan-antiviral nasal spray in patients with chronic lung disease, the company said. In June 2021, ENA Respiratory announced that it had raised A$32 million for development of INNA-051 and planned a Phase 1 trial. According to ENA, the Phase 1 study of INNA-051 demonstrated that the nasal spray was well tolerated, and the company expects to initiate a Phase 2 study that will evaluate INNA-51 against both COVID-19 and influenza in the near future.
COPD Foundation President and Chief Scientific Officer Ruth Tal-Singer said, “Millions of people are impacted by chronic lung diseases and are at a greater risk of complications from common respiratory illnesses. Our patient community surveys highlight an urgent need for treatments that prevent flare-ups triggered by viral infections, now more than ever. This fast-acting nasal spray could be used before or shortly after virus exposure to help the body respond faster and reduce the chances of complications. We are excited to partner with ENA Respiratory to advance the development of INNA-051. Together, we will leverage our current improved understanding of the role of the lung microbiome and viruses in poor outcomes in COPD, including infectious exacerbations.”
ENA Respiratory CEO Christophe Demaison commented, “People with chronic lung diseases continue to be impacted not just by the COVID-19 pandemic but by the resurgence of other common respiratory viruses. There continues to be a need for convenient treatments that can be used over the winter months or after known short-term exposure to a respiratory virus, to reduce the incidence of acute exacerbations of patients with chronic lung diseases. We are thrilled to partner with the COPD Foundation to support the clinical development of INNA-051 in chronic lung diseases. They bring significant scientific and medical expertise in addition to providing access to patient feedback on the adoption of INNA-051 by this patient population.”
Read the ENA Respiratory press release.
