• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to secondary sidebar

OINDPnews


Intertek banner
  • Home
  • News
    • Business
    • Features
    • Medical
    • Regulatory
    • Products and Services
    • People
  • Events
  • Suppliers
    • Supplier listing and advertising options
    • Capsules and blisters
    • Consultants
    • Contract research
    • Contract manufacturing
    • Devices
    • Education
    • Excipients
      • Clinical Technology
    • Filling equipment
    • Instruments
    • Particle manufacturing
    • Software and modeling
  • Jobs
  • Resources
    • Webinars
    • White papers
  • LGWP Propellants
    • HFA 152a
    • HFO-1234ze(E)
    • LGWP Regulation
  • Contact

Bryn Pharma presents data from Phase 1 study of its intranasal epinephrine

Bryn Pharma announced the publication of a poster presenting data from a Phase 1 PK/PD study of its BRYN-NDS1C intranasal epinephrine, which is delivered via an Aptar Pharma Bidose nasal device. In October 2019, Bryn announced that it had raised $17.5 million for development of BRYN-NDS1C, which has received Fast Track designation from the FDA.

The study, which enrolled 95 healthy adults, compared the intranasal epinephrine with intramuscular (IM) epinephrine via EpiPen and IM epinephrine via manual syringe. According to Bryn, 2 6.6 mg doses of intranasal epinephrine resulted in increased absorption compared to a single 0.3 mg dose of IM epinephrine and 2 doses of intranasal epinephrine in the same nostril resulted in increased absorption compared to 2 doses of IM epinephrine injected in opposite thighs.

The company also said that “At most time points, a greater percentage of participants achieved epinephrine concentrations of between 100 and 200 pg/mL after 2 IN epinephrine doses in the same nostril (IN epinephrine 2 x 6.6 mg) compared with a single dose of IM epinephrine (0.3 mg).”

Bryn Pharma CEO David Dworaczyk commented, “The study demonstrated that intranasal epinephrine delivered through a bi-dose nasal spray is a potentially novel therapeutic option in anaphylactic treatment, which may allow patients to replace two auto-injectors with a single nasal device. This is a critical benefit to patients and caregivers in an emergency environment because 30% require a second dose to provide adequate treatment to a patient in anaphylaxis.”

Read the Bryn Pharma press release.

Share

published on April 6, 2020

Primary Sidebar

Sign up for our free weekly newsletter

Upcoming Events
Sponsored by Intertek

Want information about upcoming OINDP-related events delivered directly to your inbox? click here

  • June 17-June 18: Rescon Europe 2025, Paris, France
  • June 19-June 20: Metered Dose Inhaler (MDI) Technology Training Course, online
  • June 22-June 25: ISAM Congress 2025, Washington, DC, USA
  • June 25-June 25: SMI.London 2025, London, UK
  • September 18-September 19: IPAC-RS Nasal Innovation Forum, West Trenton, NJ, USA
  • See all upcoming events

    Secondary Sidebar

    Suppliers

    Capsules and blisters
    Consultants
    Contract research
    Contract manufacturing
    Devices
    Education
    Excipients
    Filling equipment
    Instruments
    Particle manufacturing
    Software and modeling
    Proveris_180x150a
    © 2025 OINDPnews