Hovione Technology completes pilot scale manufacturing for Papillon DPI blisters

Hovione Technology said that the company has completed pilot-scale blister manufacturing and filling for its Papillon dry powder inhaler. The company announced in April 2019 that it had acquired the rights to the DPI from its inventor, Klaus-Dieter Beller.

The Papillon DPI, which is formed from a single plastic part and is reusable, can hold doses of up to 50 mg and can be used for carrier-based or carrier-free formulations. According to Hovione, the device “unlocks a cost of goods per dose competitive to that of multi-dose inhalers at a fraction of the development cost and risk.”

Hovione Technology CEO Peter Villax commented, “This is an important milestone allowing Hovione Technology to deliver Papillion inhalers together with blister samples to its pharmaceutical partners with their new inhalable powder formulations in quantities suitable for initial development purposes.”

Director of Technology Development and Licensing João Ventura Fernandes added, “We are excited to be working with Harro Höfliger, who are experts in powder filling technologies and industrial filling machines to establish a pilot-scale blister manufacturing solution for our Papillon DPI. We will continue to work with this partner to develop a manufacturing solution that can be smoothly integrated into standard, industrial-scale blister filling machines capable of high-volume commercial manufacturing for pharmaceutical partners.”

Read the Hovione Technology press release.

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