Inhaled SYK inhibitor fails to meet endpoints in Phase 2 study

Rigel Pharmaceuticals’ R343 inhaled SYK inhibitor has failed to meet primary or secondary endpoints in a Phase 2 study, the company said. As a result, Rigel will discontinue development of the product for the treatment of asthma.

The company announced the launch of a Phase 2 study called SITAR ((SYK Inhibition for Treatment of Asthma with R343) in September 2012.

Rigel Chairman and CEO James M. Gower said, “This was not the result we expected based on the collection of data we had previously seen with R343 in this therapeutic area. Fortunately, we have a robust portfolio of clinical and preclinical research programs to focus on that includes Fostamatinib, R333 for discoid lupus erythematosus and R348 for dry eye. We will be reviewing our portfolio and will discuss these plans in the near-term,” he added.

Read the Rigel press release.

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